Tinker and Alliance are looking pretty shaky in the long term - Tinker just dropped out of a tournament and Alliance was unable to play games of theirs earlier today. It looks right now like they'll soon see major changes, disband, or become one team. Alliance also sponsors a League of Legends team and a few other teams in other scenes though.
I think Alliance will be fine. There was a really good interview with Loda at the Summit where he said that he has a plan/vision but Chessie's medical problems were a big blow to them (remember they were beating VG and Mushi's Team Malaysia 2-0 in China just 2 months ago). That's why Bulldog is also on a break, they don't want to play with standins.
Loda also had a good performance at the Summit recently, standing in for Tinker. Even if Alliance may not be so hot on the scene right now, the talent at the core of their team is still present.
EDIT: This also includes D2L - a relatively large DOTA league, as well as parts of CLG (CounterLogic Gaming) - http://clgaming.net/news/611-kelby-may-steps-down-as-general...