Everything from prayer upwards is better than McAfee except the Norton $#|&'s.
My standard win setup is Security Essentials, UAC up to the max and commodo firewall and Sandboxie for trainers and the like. So far nothing has passed.
Well I do make audits with other tools from time to time booted from another OS. Also blocking flash and having vmware instances for the real dangerous stuff helps.
And anything that is smart enough to subvert that is usually used by NSA and the likes and I doubt I have gotten their attention.
My standard win setup is Security Essentials, UAC up to the max and commodo firewall and Sandboxie for trainers and the like. So far nothing has passed.