He's not great because he ignored me, he's great because he made Facebook. So even if he was a complete socialite, he'd have my respect. But I like that instance because it made me think that he wasn't primarily making Facebook for money, he was making it for his own privacy.
There are good reasons to be social to people. I'm a social person. That said, I respect immensely the people who don't feel pressured to talk to every person that writes to him.