Your start-up also won't get acquired by anyone "with a market cap >75bn EUR, or turnover in the EU >7.5bn EUR/annum." That may be fine with some folks. But it's an obvious downside if you're a start-up or backer thereof.
Nobody of decent character would care about that. Building a business is supposed to be about providing quality goods and services to customers, not trying to get a payout from a big company when they acquire you.
