Affecting Coinbase[1] as well, which is ridiculous. Can't access the web UI at all. At their scale and importance they should be multi-region if not multi-cloud.
Seems the underlying issue is with DynamoDB, according to the status page, which will have a big blast radius in other services. AWS' services form a really complicated graph and there's likely some dependency, potentially hidden, on us-east-1 in there.
[1] https://status.coinbase.com