uv works great in a container, you can tell it to skip creating a venv and use the system's version of Python (in this case, let's say Python 3.14 from the official Python image on the Docker Hub).

The biggest wins are speed and a dependable lock file. Dependencies get installed ~10x faster than with pip, at least on my machine.

Both of my Docker Compose starter app examples for https://github.com/nickjj/docker-flask-example and https://github.com/nickjj/docker-django-example use uv.

I also wrote about making the switch here: https://nickjanetakis.com/blog/switching-pip-to-uv-in-a-dock...