Nothing stops you from using a self-signed certificate with a ridiculous expiration period for HTTPS between the reverse proxy and the device in question.
WireGuard can be used to create a virtualised private network, but doesn't do so on its own, or without additional infrastructure. WireGuard tunnels network packages securely, with high throughput, from an arbitrary point A to an arbitrary point B. No more, no less.
Just because it can be used to recreate VPNs traditionally used to remotely dial into a secure network zone doesn't mean it shouldn't be used in far smaller use-cases. WireGuard doesn't constitute anything like a full VPN solution on its own.