When I realized how powerful TRAMP was, I don't think I ever used screen/tmux again. I'm sure there are uses, mind. Just TRAMP fully hit all of my needs.
It really is magical, isn’t it? And although I rarely need to use it, I love the multihop setups where you can ssh to this system, then ssh again to this other, then mount an SMB filesystem using these credentials, and start editing.
Tmux's main use case is to be glue for a unix IDE.
The two use cases are rather different and the tools are very specialized for them.