I have thought about making a game or a Fallout 3/4 mod in which the player needs to assembly pieces to repair a broken vintage computer before the nuclear war, and then search for some manuals and write programs to solve quests.
That sounds fun. I tried to design an assembly game once, but found I lack the creativity to design puzzles/goals that are not just "implement this common algorithm in assembly language". The idea of bootstrapping a PC from virtual firmware and writing an OS sounds nice, though.