If it runs on Linux, it should be fairly easy to run it on MacOS through the Game Porting Toolkit. Crossover (or Porting Kit if you don't want to pay for Crossover) should handle it.
Running modern games on Linux requires Vulkan, which has iffy support in MacOS at best (and MacOS isn’t officially supported by Valve’s compatibility tools).
It is iffy but serviceable. In this case, seems like Octopath Traveller 2 Windows version works well with GPTK. I haven't tried but Whisky, or Porting Kit should be able to handle it. Reddit has some people running it at good fps.
