Yes I think you'd want to do a lot of extrapolation, at least for the next 80 years.
You could imagine a hierarchy of simulations which dynamically adjusted the level of detail. Do you simulate every cell division to see if cancer develops, or do you just do "perfect" division with a roll of the dice for a copy error? Depends on your needs.
You could imagine organs like your skin or liver have lots of redundant computations, where you can elide away details more easily. While say your brain probably depends on the idiosyncratic behavior of individual neurons bubbling up to a macroscopic level, requiring a more detailed simulation.
You could imagine a hierarchy of simulations which dynamically adjusted the level of detail. Do you simulate every cell division to see if cancer develops, or do you just do "perfect" division with a roll of the dice for a copy error? Depends on your needs.
You could imagine organs like your skin or liver have lots of redundant computations, where you can elide away details more easily. While say your brain probably depends on the idiosyncratic behavior of individual neurons bubbling up to a macroscopic level, requiring a more detailed simulation.