My personal first experience with this was Riot.js. Ultimately, I still enjoyed using it, but writing large applications in micro frameworks is hard: it feels like either the micro framework grows substantially and starts to lose its original appeal, or your application grows framework-like limbs and suddenly the appeal of using a micro-framework is somewhat diminished.

I would guess the only real way out is to always carefully constrain your scope and keep your application as simple as possible. Easier said than done...