A drive failure every 6 months almost sounds more like dirty power than dust, I’ve always kept my NAS/file servers in dusty residential environments (I have a nice fuzzy gray Synology logo visible right now) and never seen anything like that
Except for the helium-filled ones, they aren't sealed; there is a very fine filter that equalises atmospheric pressure. (This is also why they have a maximum operating altitude --- the head needs a certain amount of atmospheric pressure to float.)
Don't know the details, but dust could have been impeding the effectiveness of his fans or clumping to create other hotspots in the system (including in the PSU).