I think you're kind of "talking past me" here, in that you're replying to a different point than the one I'm making. I'm not saying that psychedelics or crackpot theories are offering some kind of insight that scientists are missing. Rather, that describing reality with contemporary human concepts is just going to be inherently limited and restricted, because of its foundation in human perception. Saying that nothing bigger than our brain exists just seems very limited and human-centric to me.