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This is the topic of epistemology of the sciences in books such as "New Direction in the Philosophy of Mathematics" [1] and happened before with problems such as the four color theorem [2] where AI was not involved.

Going back to the uninterpretable ML models in the context of AlphaFold 3, I think one method for trying to explain the findings is similar to the experimental methods of physics with reality: you perform experiments with the reality (in this case AlphaFold 3) to came up with sound conclusions. AI/ML is an interesting black-box system.

There are other open discussions on this topic. For example, can our human brain absorbe that knowledge or it is limited somehow with the scientific language that we have now?

[1] https://www.google.com.ar/books/edition/New_Directions_in_th...

[2] https://en.wikipedia.org/wiki/Four_color_theorem



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