Since we're looking towards the future and asking whether there is an advantage of the basic materials (organic vs. inoraganic) I'm talking about the physical limits of those substrates, whether there's anything special about them that allows one to process information in a way that the other can't. I.e. how many bits can be stored in a cubic centimeter of nano-structured silicon compared to a cube of carbon, oxygen, hydrogen and other organic chemistry arranged into (for example) neurons. How many TFlop/s can be fit into such a cube in principle etc. etc. Or if there are some other physical processes relevant to information processing that make carbon special. Those fundamental limits have not changed over time, the physics are the same. All that changes are how much use engineering makes of those possibilities.