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Both of these have now been observed. Of course your underlying observation holds: prokaryotes nuclei are fundamentally fragile in the face of these compounds. However, my understanding is that in both cases, it appears that microscopic pathogens are capable of rapidly evolving rudimentary mechanical barriers.

Alcohol resistance: https://www.medicalnewstoday.com/articles/322646

Bleach resistance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464077/



> it appears that microscopic pathogens are capable of rapidly evolving rudimentary mechanical barriers.

Probably/hopefully at great cost to the organism that would ordinarily allow it to be out-competed.

This does pose a problem, however. Especially in environments where frequent sterilization takes place.




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