It is indeed huge. It might be coming as a shock that there was no vaccine for this, but it would make sense if you look at the demographics and geography that gets affected by malaria, dengue. And that truly makes it huge. Hope this is accessible as well. Now I hope my country gets an approved dengue vaccine. I had it once, won’t wish to my enemies. I’d rather take covid any day.
Beyond demographics and geography, malaria is just hard. It's not a virus with fairly stable antigenic targets - it's a parasite that readily develops resistance to things.
This is indeed huge, even if the effect is only modest on a per-person basis, because we're still talking about a tremendous number of the world's population being protected.
