"The late John P. Cleary, MD, explained that we are likely to experience strong cravings for substances like alcohol when our NAD+ receptor sites are empty. That’s because alcohol drives the formation of the chemical compound acetaldehyde, which then interacts with dopamine to yield morphine-like compounds that temporarily quell cravings and withdrawal symptoms. When the NAD+ receptor sites become unoccupied again, however, the withdrawal symptoms and alcohol cravings come rushing in, driving us back to the bottle."
https://www.webmd.com/mental-health/addiction/nad-therapy-ad...
https://pubmed.ncbi.nlm.nih.gov/31917996/
https://www.mdpi.com/2076-3921/9/5/425
"The late John P. Cleary, MD, explained that we are likely to experience strong cravings for substances like alcohol when our NAD+ receptor sites are empty. That’s because alcohol drives the formation of the chemical compound acetaldehyde, which then interacts with dopamine to yield morphine-like compounds that temporarily quell cravings and withdrawal symptoms. When the NAD+ receptor sites become unoccupied again, however, the withdrawal symptoms and alcohol cravings come rushing in, driving us back to the bottle."