It depends what you mean by state-of-the-art, but it's possible with dh-virtualenv: https://github.com/vincentbernat/pragmatic-debian-packages/t... (not something that can become an official package as it goes against Debian policies)

> that ships it's own dependencies

You mean a link to a malformed .deb packages?

It's not difficult to do but it's also the wrong way to do it.

Honestly, there is a lot more I'd like to do with my life than caring about some debian packaging practices when all I want to do is ship a company's internal application with it's exact dependency versions. But it needs to work, and, e.g. "The virtualenv relocate-able flag has been always experimental, and never really worked;"

So in practice we're back to shipping whole distributions using Docker (or, like we did, abandon Python as an option for development but keep .deb packages for deployment).