Correct: they will work about as well as DNS-based adblockers. The "cosmetic blocks" you depend on in uBlock Origin to block same-origin and in-page elements, the things that make Fandom wikis usable, will not work.
I had to check what you meant and turned of uBlock on a Fandom wiki. Ye, well, those popup ads are really distracting. Even pop-up video ads. Following your scrolling around.
It's good to remind oneself about how the internet looks like to most people ...
