I just built a desktop machine with such a board, a matching Ryzen and 128GB Kingston ECC memory. Works like a charm, the only problem is the on-board Intel Ethernet chip which ignores Wake-on-LAN (although it's supposed to handle it) so I had to add a PCIe ethernet card to get WoL running. Asus and Intel seem to discuss whose fault it is since two years, sigh.
https://rog.asus.com/forum/showthread.php?112750-List-Asus-M...
I just built a desktop machine with such a board, a matching Ryzen and 128GB Kingston ECC memory. Works like a charm, the only problem is the on-board Intel Ethernet chip which ignores Wake-on-LAN (although it's supposed to handle it) so I had to add a PCIe ethernet card to get WoL running. Asus and Intel seem to discuss whose fault it is since two years, sigh.