I really don't like the idea that Shopify adopted React so deeply (Polaris is an example), not because I am a Vue developer but I would prefer Shopify to not be so opinionated about any framework.
SalesForce built their Lightning framework with web components. It's a complete dumpster fire. Front end has settled on React for a reason; it's the best way to build UIs for the web.
VanillaJS is very advanced nowadays.