I think you're not understanding. While a bunch of people losing money is bad, it wouldn't create another Great Depression, per se. A huge investment bank with millions of counterparties going under absolutely could cause massive, long term damage to both the financial markets and the real economy. For example, people losing their hats in crypto wouldn't cause commercial paper markets to dry up. A big IB going down almost did in 2008. That would have resulted in huge businesses that employed, collectively, millions of people becoming effectively insolvent. Now you're talking about a Great Depression. Big difference. This is where the keyword "systemic" comes into play–as in, this entity is a critical node in the system. Its collapse could jeopardize the system.
Anyone with a smart phone can now spend their life savings on crypto or sports betting with almost zero friction.
We have a trillion each in student loans, auto, and credit card debt. Those (besides student loans) have requirements for credit worthiness. So those people were screened and some weren’t allowed to take on debt.
Not handled well (or ignored because it’s not viewed as a systemic risk), it’s a non-negligible portion of the population that is financially wrecked and unable to meet their debt obligations. And we can’t just make policy that says the idiots that blew their money on gambling and crypto don’t need to pay back their debt… it gets ugly fast.