Maybe not today, if you haven't saved, but if you have no major debt now, there is noplace in the country where six figures won't allow you to buy a house once you have a downpayment. Mortgages are cheaper than rent, and you're presumably living somewhere right now.
What is your definition of house? Does a studio condo count? And how far of a commute are you talking about?
Let's take Mountain View. Looking at "houses" and "townhouses" on Zillow, the cheapest one is this one[1] for $1,295,000. Zillow says the estimated monthly cost is $6,176. I don't think that's possible on a $100k salary once you factor in taxes. Zillow also says the rent "Zestimate" is $3,949/mo, so Zillow thinks it would be cheaper to rent than to buy. One hypothetical reason that renting could be cheaper than buying is that landlords buy for the expected price growth rather than just for the rental income.
> you're presumably living somewhere right now.
Maybe with roommate(s). If you buy 50% or 33% or 25% of a house with your roommate(s), that's not really $100k buying a house, that's $200k or $300k or $400k buying a house.
My point is that a six figure income makes it possible anywhere. Especially a "well over six" income. Of course you have to save, but it's ridiculous to say it's unaffordable.