I'm curious why you question CRISPR. I've worked with CRISPR; I've seen some very unexpected results from its use; I've also not really kept up with the science in the past few years.
Do you have experience working with CRISPR? Is there a study or set of studies that concerns you, or is it the reality that negative results don't get really get published?
There's nothing in the comment that "questions" CRISPR, it's just pointing out that due to the larger space of possibilities more care needs to be taken with it.
I interpreted the comments about CRISPR in the parent comment to be more or less cautionary, and I used "question" as a way to say "not sure about the benefits". Sorry if I was unclear, I will work harder on my communication.
CRISPR is basically find-and-replace with DNA. DNA expression is weird and complicated, and some bits do different things depending on the environmental context. There's a lot of potential for things to go wrong.
mRNA vaccines are injecting simple, engineered mRNA. This mRNA is expressed 100% of the time; what it does is very simple. I'd be confident using a new mRNA vaccine on day 1, so long as they're certain they picked the right protein, but I wouldn't be confident using a CRISPR treatment without a full medical trial.
Like I said, I worked with it in grad-school. I agree with you in general, though I will say that if I was in a position to get CRISPR as a treatment, I would probably have a lot of questions for my doctor, but I wouldn't dismiss it outright.
Do you have experience working with CRISPR? Is there a study or set of studies that concerns you, or is it the reality that negative results don't get really get published?