Absolutely. In the case of one uncle he was tea total, healthy diet, distance running, skiing up to his 70s when he got Alzheimer's. Declined in 2 years to the point where he couldn't be at home as he was too strong for his wife to handle. Covid proved the end of any attempt to cling on to his past as it was made illegal for family to visit him. He's gone completely now. But I suspect his physical fitness will see him last longer than he should.

My mother going this way now too.

Suspect it will be me one day.

Certainly genetic factors involved.