Using ECC is a no-brainer. Even the Raspberry Pi 4 has ECC RAM. It’s not particularly expensive and only a artificial limitation Intel has introduced for consumer products.
The Pi 4 uses DRAM with on-die ECC, which AFAIK does not provide any means of reporting errors (corrected or uncorrected) to the SoC's memory controller. It is effectively a cost-saving measure to improve DRAM yields. As such, it does little to guarantee that there are no memory errors.
