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I am not sure. According to Paul Graham, it seems to matter.

http://www.paulgraham.com/startuphubs.html



I guess when I read launch I was just thinking the app itself was focused on that city. I wasn't thinking of it in terms of your business based out of there.

If it was just the app and the app has some local components then a city you know could be helpful.

If we're talking establishment of a company, employees, etc, that is something else and way beyond my knowledge ;)




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