I think I got bit by that last night - working with sound in Mathematica, a simple MIDI tune was playing and then my MBP made a horrendously loud noise. Didn't damage the speakers, which surprised me given how loud it was. Probably the fastest I've mashed CMD-Q to quit a program though.

Had that happen to me as well on a 15-inch Touchbar. Left speaker made a horrendous sound on viewing a YouTube video and is now silent. Could probably be fixed under warranty but it's my work machine and can't have it taken from me for 2 weeks which is how long servicing / replacement usually takes in Bulgaria where I'm in.

My 2016 did that while booting. Now my left channel only produces distorted sounds. Luckily it’s still under AppleCare.