Not outright but they definitely mess with VPNs. Before net neutrality Cox for instance blocked VPNs quite a bit [1], they are holding off for now, but with net neutrality gone expect it to return. Now that they have to inspect traffic for slow lanes, they'll just put VPNs throttled down at a minimum.
> 2003—Cox and Comcast block VPNs: Back in the early internet, both Comcast and Cox Communications placed bans on Virtual Private Networks (VPNs). This was before VPNs became as ubiquitous as they are now. Back then, the only people who really used VPNs were doing so to access a work computer remotely. Which made Cox and Comcast’s choices to block them even weirder.
> 2003—Cox and Comcast block VPNs: Back in the early internet, both Comcast and Cox Communications placed bans on Virtual Private Networks (VPNs). This was before VPNs became as ubiquitous as they are now. Back then, the only people who really used VPNs were doing so to access a work computer remotely. Which made Cox and Comcast’s choices to block them even weirder.
[1] https://lifehacker.com/what-happens-when-broadband-companies...