I don't really want to contribute to the vague-ness of the discussion, and one failed SPA project is all that I can pride myself of: I'm sceptical this can be done. The synchronisation unit is the transaction: What subsets of data must be updated atomically, which business rules apply before the data can be committed, what chunks of data in the UI should be as updated as possible when an editing form is presented to the user. This requires thought and specialized code (structure).

Not saying that every form must be coded ad-hoc, but I doubt that a well-engineered SPA can be written by anyone without solid domain experience by just grabbing the next framework.