You just said the US caused the sugar trade to collapse and then said Castro destroyed trade himself. Are you referring to trade besides sugar? Why WOULDNT Cuba decide (realize) that they need to protect themselves from the US?
The Great Depression was worldwide, not US specific. Cuba was affected by it, as were many countries. And while the tariffs definitely contributed to Cuba's problems during the Great Depression, it's a little unrealistic to think Cuba would be unaffected by the Great Depression.
This was 30 years before Fidel, before the embargo. The point was, you already had this anti-US sentiment in Cuba before Fidel came to power.
US Cuban trade did not end at that point. But when Fidel came to power (30 years later), he used that anti-US sentiment to nationalize all American property in Cuba. That is what actually ended US Cuban trade.