Mostly comedy, but...

* Comedy Bang Bang - http://www.earwolf.com/show/comedy-bang-bang/

* Who Charted? - http://www.earwolf.com/show/who-charted/

* WTF with Marc Maron - http://www.wtfpod.com/

* The Indoor Kids - http://www.nerdist.com/podcast_channel/the-indoor-kids-chann...

* Brainy Gamer (hasn't been updated in a while): http://www.brainygamer.com/the_brainy_gamer/podcast/

Doug Loves Movies is also really good, although it's very guest-dependent.

Harmontown is funny too. If you find Dan Harmon abrasive, the Mitch Hurwitz episodes are funny in their own right.

I can't believe you're the only one who listed wtfpod. I love Maron.