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Very sad, for more reasons than one. For pretty much everyone, heart disease is totally preventable now. If you’re over 30, get your ApoB checked (non HDL cholesterol is a proxy), and if it’s high, get a calcium scan on your heart. If you score above zero, get your ApoB down as low as possible (which will probably require drugs - diet barely moves the needle on this for most people). Low ApoB -> no heart disease.

Source: Peter Attia


Titan (about John Rockefeller and the making of Standard Oil) and House of Morgan (about J.P. Morgan, the man and the investment bank, and the making of the modern financial system) were both excellent.


Three friends and I summited Vulcan Misti in Peru (~19k ft) over 2 days with no altitude training. All of us came from sea level, had 2 days to acclimate staying in the town nearby (~7k ft). This was a year out of college, all of us were D3 athletes so reasonably fit but probably not considered elite level fitness.

The altitude impact was no joke, but for whatever reason it affected all of us to different degrees. I just felt a little more winded than usual, had to take my time a bit but was overall fine, whereas one of the group had a rough go of it, needed frequent breaks and vomited a couple times. The other two were somewhere in between.

So I'm sure being fit helps, but it seems there's more to it than that.


I likewise had it in tea several times hiking in Peru. I personally didn’t notice any effect whatsoever, might as well have been mint tea.


Perhaps it's the fact that I was chewing them? I don't know! I'd assume tea was more potent. But I definitely had a decent reserve and was imbibing all day.


Wikipedia says that 59% to 90% of the alkaloid is absorbed when drunk as a tea [1].

[1] https://en.m.wikipedia.org/wiki/Coca


Interesting, I'd always assumed people snorted the powder because it's not absorbed if consumed orally, but apparently that's not true. Maybe just it's just for the absorption speed? So... if someone drank industrial quantities of coca tea in one go, it'd be a 2-12 hour cocaine high?


snorting means it is absorbed into the bloodstream in your nose - that is very fast. Drinking means it goes through the stomach and then is released into the intestines to be absorbed (depending on what else you ate this could be slow or somewhat fast - but always much more drawn out than snorting).


Disappointed that Nigel Pennypinch is missing from the acknowledgements.


Yes: “Hey, our company is on the market for sale and I thought you might be interested in taking a look before we accept another offer.”

And you can tailor it based on the specifics.

Working with an advisor can sometimes make this easier because they can be more direct and say things like: “Competitor X has made an offer and I know it’d make your life difficult if this asset ended up in their hands, so I wanted to give you an opportunity to take a look first.”

By the way, waiting until you get an offer to start trying to bring in competing ones isn’t great, definitely better to do that as early as you can if you’re serious about selling. You risk pissing off the interested party if you’re making them feel like they’re just being used as leverage and drag things out before giving them an answer.


All great points!

If anyone is interested in how things tend to work if you're trying to proactively sell a company (especially a profitable one), I put together a write up a while back: https://www.fivecastfinancial.com/guides/how-selling-a-compa...

(I used to be an M&A advisor - no longer!)


"If you're an optimist you're probably an idiot" has to be one of the most British hypotheses I've ever heard.


Voltaire would like a word without about optimism and stupidity being "British"

Joking aside, this whole paper had me thinking about Candide... All is for the best!

https://www.gutenberg.org/ebooks/19942


I expected Candide to be not-really-entertaining, but started it for Voltaire's thoughts, opinions, etc.

Boy, was I wrong!

It was actually funny and entertaining to read, had a great story, too.


Don't underestimate the benefit of exercise on mental performance. Your brain is a physical thing after all, mitochondria and all, and exercise improves its ability to function. Plus you'll feel way better, and probably live better for longer.


23andme will tell you your APOE genotype, one of the variants of which is a major risk factor for Alzheimer's.


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