Yesterday or the day before IIRC a fellow "WilsonPaige",
https://news.ycombinator.com/user?id=wilsonpaige
posted much earlier on Hacker News and, right in front of us, deduced that the combinationn of chloroquin + zinc lozenges would stop the covid-19 virus dead in its tracks. He announced it as such.
In return, ycombinator moderators hellbanned him and deleted some of his posts.
Now it seems WilsonPaige was right and everybody who contradicted him are, at the least, looking foolish and simply wrong.
Why did you delete most of wilsonpaige's posts? All he did is put two things together and come up with an idea that will apparently work. So he's kinda in Neils Bohr's situation with the hydrogen atom: it works, it only works here, I don't know why it works, but it works! Isn't that the essence of creativity?
Why the dunning and shunning? If the women in reasonable shoes on this bbs had any creativity we wouldn't be in a jam with Covid.
Is wilsonpaige so different in this regard from Elon Musk? Musk posts re quinone and is praised and his ideas spread. Wilsonpaige at first doubts the quinone solution, then within hours finds confirming studies, adds to it his experience with zinc antivirals and comes up with a better solution (albeit one w/o an underlying mechanism). Now you've torn his posts up and thrown them away.
"In view of the high amount of cytokines induced by SARS-CoV,22, 24 MERS-CoV,25, 26 and 2019-nCoV infections, corticosteroids were used frequently for treatment of patients with severe illness, for possible benefit by reducing inflammatory-induced lung injury. However, current evidence in patients with SARS and MERS suggests that receiving corticosteroids did not have an effect on mortality, but rather delayed viral clearance.27, 28, 29 Therefore, corticosteroids should not be routinely given systemically, according to WHO interim guidance."
Curcumin has been shown to suppress the cytokine storm.
Curcumin is found in the spice turmeric and is available in most grocery stores. Today you can buy a pound of turmeric powder for ~$6. You can buy curcumin tablets in the health & fitness section.
Other anti-inflammatory agents (NSAIDS(aspirin, buprofen, naproxen),prednisone, etc.) are not as effective.
In India children are often given a daily teaspoon of turmeric (curcumin) in milk or water. India suffered much lower SARS deaths (there are confounding factors, e.g. India's high summer heat). I expect the same to happen with covid-19.
Take curcumin papers with a pinch of salt. It's a pan assay interference compound (PAIN), prone to misleading results. Pubmed is full of thousands of papers claiming it solves all manner of medical problems, leading it to be dubbed an 'improbable natural panacea'.
See this article, by the same author as it happens.
This article https://www.sciencedaily.com/releases/2014/02/140227142250.h... by The Scripps Research Institute suggests that cytokine storm is more likely to occur in relatively young patients rather than in the very young or elderly. It further states it was the likely major cause of mortality with the 1918 flu (which killed my great-grandfather), the H1N1 "swine flu", and the H5N1 "bird-flu."
SARS-CoV-19 on the other hand seems to cause mortality more often in patients 55+ years of age rather than the relatively young. At least from the data so far. The NIH emphasized this in yesterday's WH/NIH presser.
"In view of the high amount of cytokines induced by SARS-CoV,22, 24 MERS-CoV,25, 26 and 2019-nCoV infections, corticosteroids were used frequently for treatment of patients with severe illness, for possible benefit by reducing inflammatory-induced lung injury. However, current evidence in patients with SARS and MERS suggests that receiving corticosteroids did not have an effect on mortality, but rather delayed viral clearance.27, 28, 29 Therefore, corticosteroids should not be routinely given systemically, according to WHO interim guidance."
"In most moribund patients, 2019-nCoV infection is also associated with a cytokine storm, which is characterised by increased plasma concentrations of interleukins 2, 7, and 10, ..."
Years ago one doctor (IIRC a general practioner) noticed that all his diabetes patients taking metformin never got cancer. So he wrote a letter about it. I've lost the cite.
Today everyone, even doctors, knows that high blood sugar levels increase the odds of cancer AND diabetes. That's why everyone and his dog is taking metformin and why that drug is almost always the first ingredient included in "life extension" cocktail drug tests.
High glucose creates all kinds of stresses on the body (as a diabetic I get more easily ill when glucose levels are high) but I would not be surprised if cancer has some kind of operational working like pregnancy related diabetes which then causes the high glucose levels and accelerates everything even more.
But: High glucose levels do not cause diabetes. Diabetes causes high glucose levels. Once they go up you need treatment as you either have no insulin or are producing not enough and need to mediate that. Both are diabetes.
>I would not be surprised if cancer has some kind of operational working like pregnancy related diabetes which then causes the high glucose levels and accelerates everything even more.
Ding ding ding. My wife's blood glucose levels went from normal 90's range to averaging around 120 over the summer to averaging close to 200 last December. Her liver had a heavy disease burden, and my understanding based on my own research (because none of her doctors would address it) is that this can affect insulin sensitivity, which in turn can cause elevated blood sugar. This does not seem to be a dominant effect, however, and can go the other way as well.
When it does create hyperglycemia though, it also creates an unfortunate feedback loop in that the elevated blood sugar levels can increase the cancer progression, compounding the effect.
Indeed, an additional benefit of specifically using metformin to help address both.
But guess what, nobody will bite. I had to go to some weird third party service to get a prescription and spend weeks going back and forth with oncology and endocrinology to get anyone to comment on it. Oncology said NFW with zero rationale and endo said a small starter dose with regular monitoring for lactic acidosis due to compromised liver function.
"Source: A long time back a friend of mine's brother was part of a faux-jury assembled by tobacco company lawyers to do like a focus group to research how real juries in some real trial might think/feel."
Ycombinator post<--carapace<--friend<--brother<--faux-jury<--lawyers<--tobacco company
Even facts get changed when they're nested >5 levels deep in human networks.
especially if it had no nicotine, it could help people to stop smoking who miss the fidgeting or social aspect. e-cigarettes/vaping is really good for this, because you can taper down to 0mg liquid, keep vaping until you've kicked the nicotine, and then maybe months later try to stop all together
I prefer David Deutsch's optimistic approach to our problems: use science to find solutions. Rebellion is beyond the pale. We don't need rebels; we need scientists and more good science.
"The Beginning of Infinity: Explanations That Transform the World" by David Deutsch
Is there a text focusing on the known differences between the lower dimensional spaces of 1-4 dimensions and the higher-dimensionality spaces commonly used in DNN calculations?
You might have to be a bit more specific about what exactly you are asking, but for example this paper and its references might be an interesting start: https://bib.dbvis.de/uploadedFiles/155.pdf
In return, ycombinator moderators hellbanned him and deleted some of his posts.
Now it seems WilsonPaige was right and everybody who contradicted him are, at the least, looking foolish and simply wrong.