And then it creates problem with radiation (energy dense particles travelling close to the speed of light ripping holes into 2nm chips) and heat (it turns out that coffee stays hot in a thermos for very long time)
Well the first problem you will hit I'd that very likely you will need to protect or isolate those lines from ESD. This will raise price of device and it will get denied just in these grounds.
ESD diode costs are nothing compared to the connector headers or even dealing with the mechanical complications of exposing Just One More Thing. Seriously, they're cheap.
What you are describing is going to be nightmare to work with - i.e. when you will have automatic detection of levels and it will decide to push RS232 into 3V3 MCU then you will have dead, maybe one of the kind prototype or dead expensive production device
It really depends. If you know your competitor and understand their core business, then opening garage doors can actually screw them up.
I am working in an industry where if one competitor would go open source and created decent open application, whole industry will effectively implode because end customers will always choose cheaper solution, which in case of open source would be for free.
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