The fed can take nore active measures than just managing rates. I lost some money by unexpectedly finding myself on the opposite side of US government policy - and dollar-firehose - during COVID. Shorting travel-related stocks can be a losing bet if the government wants to "shore up" share prices by directly injecting hitherto unheard of amounts of liquidity into the market.
I had early "insider" info on COVID admissions from a Pulmonologist spouse, and an understanding of exponential growth (doubling every few days).
I took the initiative to be the first person to WFH in my org, which I did as a pre-emptive quarantine as I was at risk of being infected: several of my spouse's colleagues subsequently got infected. Unfortunately, I didn't link my WFH circumstances that with investing in Zoom.