I run Fedora Kinoite full time on my primary machine, and it's great. Obviously a bit of a learning curve, but if your workflow can be achieved using Flatpaks and Toolbox, it's fine. You can (and I do) layer packages but I have only 3 or so I need to layer (asusctl, supergfxctl and asusctl-rog-gui).
My only real gripe is that Firefox still ships as an rpm in the base image. I understand that they want to include a working web browser at all costs, and I don't think they can distribute the Flatpak version with the base image, but it's annoying that I have to mess with the image (removing Firefox) to then re-install the (more up to date) Flatpak.
And if you have an nvidia card and want to use cuda, Bazzite offers the same experience as Kinoite, but with nvidia drivers preinstalled out of the box.
My only real gripe is that Firefox still ships as an rpm in the base image. I understand that they want to include a working web browser at all costs, and I don't think they can distribute the Flatpak version with the base image, but it's annoying that I have to mess with the image (removing Firefox) to then re-install the (more up to date) Flatpak.