IMO healty food and reduced calories is all you need to worry about. Does it matter if you are getting a calorie from fat, sugar, protein, alcohol, etc?
Watch the video, especially the part covering the biochemistry. Fructose interferes with satiety signaling (leptin, ghrelin), which forces eating beyond caloric needs.
An unprocessed strawberry is healthy because the fiber limits the rate at which fructose leaks out of the chunks in your gut. Blend or freeze that same strawberry and it becomes junk candy.
