Sure! I run qmail, dovecot, djbdns on one of their stock FreeBSD 11-RELEASE images on their cheapest static-IPV4 level. Blacklisting hasn't been an issue (knock wood) anywhere except for Yahoo and they were impossible mail recipients when I had a real business static CIDR space so screw em. The VSP is great about maintaining the inverse address mapping. I have the SPF records, not sure that they do anything.
lwq.html or the OS's port collection will point you to DJB's (mandatory) djbdns config instructions. Do you remember how to manually edit DNS zone records? He uses a unique format but you'll still need to remember which resource records to use. By now there must be great online DNS resources? I don't know them. O'Reilly's dead tree books weigh on my bookshelf.
dovecot comes with excellent documentation and man pages and worked out box of the FreeBSD port collection.
I left out one other use. I subscribe to about 30 mail lists, all but NANOG o/s related. I have those emailed to the VSP instance and use a really simple mail2news.py script to pipe it to rnews for forwarding to a private INN server that sits behind a dynamic IP to preserve and read mail lists with a newsreader as $DIETY intended. With a static presence and a cheap VSP it's so much easier to make things work the way you like them. I hope you try it and get into it as much as I do.
